Bone marrow necrosis in systemic lupus erythematous patient

Authors

  • Cláudia Hilbig PUC-SP/FCMS
  • José Victor Martinez PUC-SP/FCMS
  • José Eduardo Martinez PUC-SP/FCMS

DOI:

https://doi.org/10.5327/Z1984-4840201625947

Keywords:

lupus erythematous, systemic, pancytopenia, necrosis, bone marrow

Abstract

The hematological manifestations of systemic lupus erythematous (SLE) are causes of morbidity and increased risk of mortality. Young patient, female, with SLE and antiphospholipid syndrome (APS) had severe pancytopenia after urinary tract infection. A biopsy of the bone marrow (BM) showed necrosis and fibrosis. The most common pathophysiological mechanism for pancytopenia is the production of peripheral antibodies. However, pancytopenia with BM aplasia or necrosis is rare. BM necrosis is more common with neoplastic diseases, severe infections or sickle cell anemia but is also reported for patients with SLE. It is seen more rarely in patients with primary APS. Changes in the BM microcirculation lead to ischemia and subsequent necrosis. The main complications are pancytopenia and embolism. BM necrosis has been appointed in few clinical studies as a possible cause for pancytopenia in SLE patients. Among the findings, BM necrosis was present in 19% of the patients. BM necrosis is a relatively rare and poor prognosis entity.

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Author Biographies

Cláudia Hilbig, PUC-SP/FCMS

Especializanda em Reumatologia

José Victor Martinez, PUC-SP/FCMS

Estudante de Medicina

José Eduardo Martinez, PUC-SP/FCMS

Titular do Departamento de Medicina

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Published

2017-01-23

How to Cite

1.
Hilbig C, Martinez JV, Martinez JE. Bone marrow necrosis in systemic lupus erythematous patient. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2017Jan.23 [cited 2024Jul.3];18(4):187-92. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/25947

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Section

Review