Use of cannabidiol in children and adolescents with autism spectrum disorder
a scoping review
DOI:
https://doi.org/10.23925/2176-2724.2025v37i4e72186Keywords:
Autism spectrum disorder, Children, Cannabidiol, Efficacy, SafetyAbstract
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social communication and leads to repetitive behaviors. Treatment involves therapeutic and pharmacological approaches, with cannabidiol (CBD) emerging as a promising alternative to reduce disruptive symptoms and improve social interaction. Objective: To analyze the effects of cannabidiol in treating behavioral symptoms in children and adolescents with ASD, considering its efficacy, safety, and drug interactions. Methods: This review analyzed four studies involving a total of 350 participants, suggesting a reduction in behavioral symptoms. In addition, there were reports of improved communication and mild adverse effects. Results: The studies included in this scoping review suggest that CBD may have potential beneficial effects in ASD, but there was no consensus on the superiority of whole-plant extract compared to isolated CBD compounds. Effects vary depending on formulation and symptom severity, with divergent assessments. The safety of long-term use is not well established, and there are concerns regarding drug interactions and metabolic and cardiovascular risks. Conclusion: This scoping review mapped the available scientific evidence on the use of cannabidiol in children and adolescents with Autism Spectrum Disorder. The findings indicate that cannabidiol has therapeutic potential for behavioral symptoms of ASD; however, the heterogeneity of studies and the lack of long-term research limit definitive conclusions about its efficacy and safety. Further research is needed to fill knowledge gaps and support clinical practice.
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Copyright (c) 2025 Joao Victor Bomtempo de Castro, Marcelo Trindade Junior, Valeriana de Castro Guimarães, Deborah Branco Ferreira Perilo, Neuma Chaveiro
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