Auditory monitoring in adults undergoing chemotherapy with carboplatin

Abstract

Purpose: To characterize the hearing of adult patients undergoing chemotherapy with carboplatin using two sequential audiological tests during chemotherapy treatment. Methods: Prospective and observational. The participants were six adult subjects between 53 and 59 years and 11 months, undergoing chemotherapy treatment with carboplatin subjected to a battery of audiological exams. Data were analyzed using the ANOVA test, z test for proportions and Wilcoxon signed-ranks test. The adopted significance was 5% (p ≤ 0.05). Results: An increase in hearing thresholds was observed, particularly in the higher frequencies, but there was no significance. It was also observed an increase in the signal / noise ratio of transient evoked otoacoustic emissions and for distortion product, but without statistical significance. Conclusion: No statistically significant changes regarding the hearing thresholds and responses of otoacoustic emissions were observed, however it could be noted an increase in hearing thresholds, especially at high frequencies, as well as the increased amplitude on the responses in otoacoustic emissions.