Necrólise epidérmica tóxica secundária ao uso de hidroxicloroquina em paciente com Chikungunya: relato de caso

Renata Cândido Borges; Luis Arthur Brasil Gadelha Farias; Rosa Priscila Oliveira Monte Andrade; Edmara Bezerra Guerra da Costa; Antônio Rene Diógenes de Sousa; Maria Araci Pontes Aires

doi:10.23925/1984-4840.2019v21i1a9

Authors

Renata Cândido Borges Centro Dermatológico Dona Libânia (CDERM), Serviço de Dermatologia - Fortaleza (CE), Brasil. http://orcid.org/0000-0002-3633-2811
Luis Arthur Brasil Gadelha Farias Universidade Federal do Ceará (UFC), Faculdade de Medicina - Fortaleza (CE), Brasil. http://orcid.org/0000-0002-8978-9903
Rosa Priscila Oliveira Monte Andrade Hospital Geral de Fortaleza (HGF), Serviço de Reumatologia - Fortaleza (CE), Brasil. http://orcid.org/0000-0002-0711-1999
Edmara Bezerra Guerra da Costa Hospital Geral de Fortaleza (HGF), Serviço de Reumatologia - Fortaleza (CE), Brasil. http://orcid.org/0000-0003-3221-8461
Antônio Rene Diógenes de Sousa Centro Dermatológico Dona Libânia (CDERM), Serviço de Dermatologia - Fortaleza (CE), Brasil. http://orcid.org/0000-0002-5926-9157
Maria Araci Pontes Aires Centro Dermatológico Dona Libânia (CDERM), Serviço de Dermatologia - Fortaleza (CE), Brasil. http://orcid.org/0000-0002-7292-8452

DOI:

https://doi.org/10.23925/1984-4840.2019v21i1a9

Keywords:

Chikungunya fever, hydroxychloroquine, drug-related side effects and adverse reactions, drug eruptions, Stevens-Johnson syndrome, skin diseases

Abstract

Toxic epidermal necrolysis is a dermatological syndrome of pharmacological hypersensitivity. Its association with hydroxychloroquine is extremely rare. Herein, we report a case of a 48-year-old obese female patient, who after Chikungunya’s disease progressed with persistent joint pain and was treated with hydrochloroquine, evolving with toxic epidermal necrolysis compatible erythematous-bullous-scaly lesions. The patient progressed with complete remission after 1 month of supportive and antibiotic therapy for secondary infection.

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Author Biography

Luis Arthur Brasil Gadelha Farias, Universidade Federal do Ceará (UFC), Faculdade de Medicina - Fortaleza (CE), Brasil.

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References

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