Henoch-Schönlein purpura in adult

Authors

  • Jorge Luiz de Carvalho Mello Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil.
  • Luis Paulo Cachola Gallo Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil. http://orcid.org/0000-0002-5021-9030
  • Kayane Ridolfi Carvalho Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil. http://orcid.org/0000-0002-4403-4275
  • Juliana Monroe Silva Hospital das Clínicas Samuel Libânio (FUVS) – Pouso Alegre (MG), Brasil. http://orcid.org/0000-0001-8151-8685
  • Sebastião Jupiaçara Guimarães Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil. http://orcid.org/0000-0002-5441-8256
  • Carolina Fernandes Pereira Hospital das Clínicas Samuel Libânio (FUVS) – Pouso Alegre (MG), Brasil. http://orcid.org/0000-0002-7567-6983

DOI:

https://doi.org/10.23925/1984-4840.2018v20i3a10

Keywords:

Schoenlein-Henoch purpura, vasculitis, leukocytoclastic, cutaneous, vascular diseases

Abstract

Henoch-Schönlein purpura (HSP) is a vasculitis characterized by the deposit of IgA causing a leukocytoclastic reaction. Its etiology is not fully understood. It mainly affects children, and the involvement in adults is usually rarer and with worse prognosis. The most affected sites make up a tetrad: skin, joints, gastrointestinal tract and kidneys. The diagnosis is clinical, with the majority of patients presenting elevated serum IgA, and skin biopsy reveals a leukocytoclastic vasculitis. It usually is a benign and self-limiting disease, with supportive therapy being the basis of treatment along with rest and analgesia, and the use of corticosteroids in more intense cases. We reported the case of the disease in a 46-year-old male subject, admitted with palpable purpura, proteinuria, elevated serum IgA level and leukocytoclastic vasculitis on cutaneous biopsy. He was treated with corticosteroid therapy, evolving with significant improvement of the condition.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Jorge Luiz de Carvalho Mello, Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil.

Professor de Clínica Médica da Universidade do Vale do Sapucaí

Chefe do Serviço de Clínica Médica do Hospital das Clínicas Samuel Libânio em Pouso Alegre-MG

Luis Paulo Cachola Gallo, Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil.

In memoriam

Kayane Ridolfi Carvalho, Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil.

Acadêmica de Medicina da Universidade do Vale do Sapucaí

Juliana Monroe Silva, Hospital das Clínicas Samuel Libânio (FUVS) – Pouso Alegre (MG), Brasil.

Médica residente em Clínica Médica do Hospital das Clínicas Samuel Libânio

Sebastião Jupiaçara Guimarães, Universidade do Vale do Sapucaí (UNIVAS), Faculdade de Medicina – Pouso Alegre (MG), Brasil.

Professor Titular de Clínica Médica da Universidade do Vale do Sapucaí

Carolina Fernandes Pereira, Hospital das Clínicas Samuel Libânio (FUVS) – Pouso Alegre (MG), Brasil.

Médica Residente em Clínica Médica do Hospital das Clínicas Samuel Libânio

References

Kang Y, Park JS, Ha YJ, Kang MI, Park HJ, Lee SW, et al. Differences in clinical manifestations and outcomes between adult and child patients with Henoch-Schönlein purpura. J Korean Med Sci. 2014;29(2):198-203. http://dx.doi.org/10.3346/jkms.2014.29.2.198

Azevedo CB, Villella GMS, Nicolato AM, Carmo VMP, Schlaucher SH, Bonfante HL. Unusual face involvement in Henoch-Schönlein purpura. Rev Bras Reumatol. 2009;49(6):735-40. http://dx.doi.org/10.1590/S0482-50042009000600010

Yagüe MS, Gomà MC, Muñoz RC, Balboa IV. Henoch- Schönlein purpura. SEMERGEN - Medicina de Familia. 2011;37(3):156-8. http://dx.doi.org/10.1016/j.semerg.2010.07.010

Hong S, Ahn SM, Lim DH, Ghang B, Yang WS, Lee SK, et al. Late-onset IgA vasculitis in adult patients exhibits distinct clinical characteristics and outcomes. Clin Exp Rheumatol. 2016;34(3 Supl. 97):S77-83.

Calvo-Río V, Loricera J, Ortiz-Sanjuán F, Mata C, Martín L, Alvarez L, et al. Revisiting clinical differences between hypersensitivity vasculitis and Henoch–Schönlein purpura in adults from a defined population. Clin Exp Rheumatol. 2014;32(3 Supl. 82):S34-40.

Kukrety S, Vimalachandran P, Kunadharaju R, Mehta V, Colanta A, Hazeem MA. Henoch Schönlein purpura as a cause of renal failure in an adult. Case Rep Med. 2016;2016(Article ID 789037):3. http://dx.doi.org/10.1155/2016/7890379

Alfredo CS, Nunes NA, Len CA, Barbosa CM, Terreri MT, Hilário MO. Henoch-Schönlein purpura: recurrence and chronicity. J Pediatr (Rio J). 2007;83:177-80. https://doi.org/doi:10.2223/JPED.1595

Jarasvaraparn C, Lertudomphonwanit C, Pirojsakul K, Worawichawong S, Angkathunyakul N, Treepongkaruna S. Henoch-Schönlein without purpura: a case report and review literature. J Med Assoc Thai. 2016;99(4):441-5.

Kraft DM, Mckee D, Scott C. Henoch-Schönlein purpura: a review. Am Farm Physician. 1998;58(2):405-8.

Robson WL, Leung AK. Henoch-Schönlein purpura. Adv Pediatr. 1994;41:163-94.

Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B. IgA vasculitis (Henoch Schönlein purpura) in adults: diagnostic and therapeutic aspects. Autoimmun Rev. 2015;14(7):579-85. http://dx.doi.org/10.1016/j.autrev.2015.02.003

Zurada JM, Ward KM, Grossman ME. Henoch- Schönlein purpura associated with malignancy in adults. J Am Acad Dermatol. 2006;55(5 Supl.):S65-70. http://dx.doi.org/10.1016/j.jaad.2005.10.011

Downloads

Published

2018-12-03

How to Cite

1.
Mello JL de C, Gallo LPC, Carvalho KR, Silva JM, Guimarães SJ, Pereira CF. Henoch-Schönlein purpura in adult. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2018Dec.3 [cited 2024Dec.21];20(3):174-7. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/33097

Issue

Vol. 20 No. 3 (2018)

Section

Case Report

License

Os autores no momento da submissão transferem os direitos autorais, assim, os manuscritos publicados passam a ser propriedade da revista.

O conteúdo do periódico está licenciado sob uma Licença Creative Commons 4.0, esta licença permite o livre acesso imediato ao trabalho e que qualquer usuário leia, baixe, copie, distribua, imprima, pesquise ou vincule aos textos completos dos artigos, rastreando-os para indexação, passá-los como dados para o software, ou usá-los para qualquer outra finalidade legal.

Crossref
Scopus
Google Scholar
Europe PMC