Effects of lidocaine patch on orofacial pain and sleep quality in patients with bruxism

Authors

  • Ana Luiza Hehnes Silbiger Martins Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde
  • Gabriela Gerenutti Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde
  • Marli Gerenutti Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

DOI:

https://doi.org/10.23925/1984-4840.2025v27a21

Keywords:

Bruxism, Temporomandibular Joint Dysfunction Syndrome, Facial Pain, Dental Occlusion, Lidocaine, Sleep Quality

Abstract

Introduction: Sleep bruxism is a movement disorder characterized by teeth grinding or clenching, which results in rhythmic contractions of the masseter muscles. These contractions can increase tooth compression during sleep compared to wakefulness. This mechanical stress may contribute to chronic orofacial pain, tooth fractures, dental wear, and temporomandibular joint damage. Objective: To evaluate the effects of applying a 5% lidocaine patch on orofacial pain and sleep quality in patients with sleep bruxism. Methodology: This was a pilot outpatient treatment study, open-label, self-controlled, with both quantitative and qualitative assessments. It included 10 volunteers diagnosed with sleep bruxism for over five years. Participants self-applied a 5% lidocaine patch at a daily dose of 350 mg, worn nightly for 8 hours over a 30-day
period. Sleep quality and pain levels were assessed using a self-reported questionnaire. Results: Nine patients adhered satisfactorily to the treatment protocol. Significant improvements in orofacial pain associated with sleep bruxism were observed on days 10, 20, and 30 of treatment (p < 0.001). Improved sleep quality was also reported at the end of the
intervention (p < 0.005). As expected, teeth grinding behavior remained unchanged (p > 0.05). Conclusion: The use of a 5% lidocaine patch as an adjunct treatment for moderate to severe sleep bruxism promoted muscle relaxation, reduced orofacial pain, improved sleep quality, and was well tolerated, with no adverse reactions reported.

Author Biographies

Ana Luiza Hehnes Silbiger Martins, Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

Possui graduação em Odontologia pela Universidade Paulista (2014). Especialização em ortodontia, na área de alinhadores ajustáveis, pela instituição de ensino FACOP (2018).  Mestranda do Programa de Pós-Graduação em Biomateriais e Medicina Regenativa da PUC-SP (2023).  

 

Marli Gerenutti, Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

Desenvolve pesquisas cientifico-tecnológicas aplicadas à área médica. Docente do Programa de Pós-Graduação em Biomateriais e Medicina Regenerativa da PUC-SP e do Programa de Pós-Graduação em Educação para as Profissões da Saúde. Membro do Comitê de Ética em Pesquisa com Seres Humanos (CEP-PUC/SP). Farmacêutica Bioquímica, formada pela UNESP (1988), na modalidade Análises Clínicas e Toxicológicas. Bolsista do CNPq Nível Mestrado (1989-1990) e Nível Doutorado (1991-1996) pela Faculdade de Medicina Veterinária e Zootecnia da USP (FMVZ-USP), na área de Patologia Experimental e Comparada. Pós-Doutorado - Bolsista Rhae/CNPq do Centro Experimental da Marinha (CEA-ARAMAR. 1998-1999). Consultora do Banco Mundial (2011, Projeto PROBIO II -13/2010 SVS) para elaboração de Monografias de Drogas Vegetais. Docente do curso de Medicina da PUC-São Paulo (2019). Docente da Universidade de Sorocaba (1995-2019), Coordenadora do Curso de Farmácia (1997-2001), Pró-Reitora de Pós-Graduação e Pesquisa (2002-2010), Vice-Reitora (2006-2009), Coordenadora do Programa Ciências sem Fronteiras (2011-2013), Coordenadora do Programa o PIBIC/CNPq (2010-2013), Presidente do Simpósio Internacional sobre Cogumelos no Brasil (V SICOG - 2010 e VIII SICOG - 2015), Docente Permanente do Programa de Pós-Graduação em Ciências Farmacêuticas (2008-2019) e do Programa de Pós-Graduação em Processos Tecnológicos e Ambientais (2016-2019). Coordenadora do Projeto do Laboratório de Pesquisas Toxicológicas - Lapetox ( Apoio FINEP 2010-2018). Membro da Câmara Setorial de Fungicultura do Governo do Estado de São Paulo (desde 2016).

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Published

2025-09-08

How to Cite

Martins, A. L. H. S. ., Gerenutti, G., & Gerenutti, M. (2025). Effects of lidocaine patch on orofacial pain and sleep quality in patients with bruxism. Revista Da Faculdade De Ciências Médicas De Sorocaba, 27(Fluxo contínuo), e68577. https://doi.org/10.23925/1984-4840.2025v27a21

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