Positioning research and Scholarly Innovation within a “transdisciplinary” approacht

the case of the South African indigenous plant Rooibos (Aspalathus linearis) and its potential as an ergogenic aid

Authors

  • Simeon Davies Cape Peninsula University of Technology
  • Jeanine Marnewick Cape Peninsula University of Technology
  • Dirk Bester Cape Peninsula University of Technology
  • Oviety Kamati Cape Peninsula University of Technology

DOI:

https://doi.org/10.23925/2179-3565.2023v14i4p84-103

Keywords:

Transdisciplinary, Ergogenic, Rooibos, Sustainability

Abstract

Based on the shared expertise of two research entities at the Cape Peninsula University of Technology (CPUT) a transdisciplinary (TD) research approach was adopted to investigate whether Rooibos an indigenous South African plant with its unique bioactive compounds modulates oxidative stress and potentially acts as an ergogenic supplement. Due to the nature of this unique biotechnology and sport business collaboration along with support from the South African Rooibos Council (SARC) and associated academic stakeholders, various beneficial outcomes were anticipated, including: 1) to provide scientific findings informed by the innovative technologies that measure metabolic and gene-diet interaction responses to phenolic-rich Rooibos; 2) to assess the potential of Rooibos to modulate oxidative stress during exercise and underscore its anticipated ergogenic properties; 3) to utilize scientifically derived evidence to beneficiate Rooibos in the lucrative sport supplement market; 4) to provide rationale to optimize the equitable sharing of benefits derived from Rooibos to the relevant indigenous communities, and 5) to enhance sustainable economic benefits derived from various policy enactments including the Protected Designation of Origin (PDO) status. The findings from two randomized double-blinded placebo controlled intervention trials provide a strong indication that the unique bioactive compounds of Rooibos may have benefits for exercise performance and recovery and as a potential ergogenic supplement, which may have further positive ramifications for the Rooibos value chain in terms of beneficiating Rooibos. Additionally, the TD approach has acknowledged the importance of indigenous biological resources, and the commitment to share sustainable economic benefits with traditional knowledge holders in a fair and equitable way.

References

Ahmetov, I.I. Hall, E.C.R. Semenova, E.A. Pranckevičienè, E., & Ginevičienè, V. (2022). Advances in sports genomics. Advances in Clinical Chemistry, 107, 215-263. doi: 10.1016/bs.acc.2021.07.004

Amnesty International (2020). Broken and unequal, the state of education in South Africa. https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Appel, J., & Kim-Appel, D. (2018). Towards a Transdisciplinary View: Innovations in Higher Educat. International Journal of Teaching and Education, VI(2), 61-74, https://10.20472/TE.2018.6.2.004

Arai, S. (1996). Studies on functional foods in Japan–state of the art, Bioscience, Biotechnology, and Biochemistry, 60 (1), 9–15.

Back, S.M., Greenhalgh-Spencer, H., & Frias, M.F. (2015). ‘The application of

transdisciplinary theory and practice to STEM education’, in Y. Rosen, S. Ferrara & M. Mosharraf (eds.), Handbook of research on technology tools for real-world skill development (pp. 42–67), IGI Global, Hershey, PA.

Bala, A., & Bhalla, S. (2022). Ergogenic aids for improving athletes’ performance: An overview. International Journal of Physiology, Nutrition and Physical Education, 7(1), 371-373.

Bishop, D. (2010). Dietary supplements and team-sport performance. Sports Medicine, 40, 995–1017. doi: 10.2165/11536870-000000000-00000

Blommaert, K.L.J., & Steenkamp, J. (1978). Tannien-en moontlike kafeieninhoud van rooibostee, Aspalathus (subgen. Nortiera) linearis (Brum. Fil) R. Dahlgr. Agroplantae, 10, 49.

Bongiovanni, T., Lacome, M., Fanos, V., Martera, G., Cione, E., & Cannataro, R. (2022). Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives. Proteomes, 10, 27. https://doi.org/10.3390/ proteomes10030027

Born, J., Linder, H.P., & Desmet, P. (2007), The Greater Cape Floristic Region. Journal of Biogeography, 34, 147-162. https://doi.org/10.1111/j.1365-2699.2006.01595.x

Bragagna, L., Kamati, O.V., Stürmer, V., Gassner, M., Maqboul, L., Davies, S.E.H., Marnewick, J.L., & Wagner, K-H. (2023). Single-dose effect of rooibos herbal tea on oxidative stress markers in healthy males. Redox Congress. June 6–9, 2023, in Vienna, Austria.

Bouchard, C., Rankinen, T., & Timmons, J.A. (2011). Genomics and Genetics in the Biology of Adaptation to Exercise. Comprehensive Physiology, 1, 1603–1648.

Brennenraedts, R., Bekkers, R., & Verspagen, B. (2006). The different channels of university industry knowledge transfer: Empirical evidence from biomedical engineering. https://citeseerx.ist.psu.edu/viewdoc/download ?doi=10.1.1.543.6736&rep=rep1&type=pdf

Bruce, S.J., Breton, I., Decombaz, J., Boesch, C., Scheurer, E., Montoliu, I., Rezzi, S., Kochhar, S., & Guy, P.A. (2010). A plasma global metabolic profiling approach applied to an exercise study monitoring the effects of glucose, galactose and fructose drinks during post-exercise recovery. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 878(29), 3015–3023.

Cardenas, D., & Fuchs-Tarlovsky, V. (2018). Is multi-level marketing of nutrition supplements a legal and an ethical practice? Clinical Nutrition, ESPEN 25, 133–138.

Chuenpagdee, R. (2018), Transdisciplinarity for small-scale fisheries governance: Analysis and practice, Springer, St. John’s.

Cowling, R.M. (1992). The ecology of fynbos: nutrients, fire and diversity. Oxford University Press, Cape Town.

Cape Peninsula University of Technology (CPUT) (2022). Cape Peninsula University of Technology Vision.

https://www.cput.ac.za/research-technology-and-innovation/centres.

Department of Agriculture, Forestry & Fisheries (DAFF) (2013): A Profile of the South African Rooibos Tea Market Chain. http://webapps.daff.gov.za/AmisAdmin/upload/ROOIBOS%20TEA%20MARKET%20VALUE%20CHAIN%20PROFILE%202014.pdf

Daher, J., Mallick, M., & El Khoury, D. (2022). Prevalence of Dietary Supplement Use among Athletes Worldwide: A Scoping Review. Nutrients, 14, 4109. https://doi.org/10.3390/nu14194109

Daneshpour, H., & Kwegyir‑Afful, E. (2022). Analysing Transdisciplinary Education: A Scoping Review. Science & Education, 31, 1047–1074. https://doi.org/10.1007/s11191-021-00277-0

Davies, S.E.H., Marnewick, J.L., West, S., Taliep, S.M., & Rautenbach, F. (2018). Antioxidant supplementation and exercise induced fatigue: The potential of rooibos aspalathius linearis. 7th International Ergonomics Conference, ERGONOMICS 2018. Zadar, Croatia, 13-16 June 2018: ISSN 1848-9699 (Print) ISNN 2584-5012 (USB), pages 95-103.

Davies, S.E.H., Marnewick, J.L., and West, S. (2019a). Rooibos Aspalathus linearis – Can it reduce the incidence and severity of acute mountain sickness? A case study of Aconcagua (6962 m). African Journal of Physical Activity and Health Sciences, 25(2): 232-251. 2019-07-30. https://www.ajol.info/index.php/ajpherd/article/view/188543

Davies, S.E.H., Marnewick, J.L., West, S., Taliep, S.M., Rautenbach, F., & Gamieldien, R. (2019b). ‘The efficacy of rooibos Aspalathus linearis as an ergogenic aid during exercise’. International Journal of Human Factors and Ergonomics, 6(1), 88-102. DOI:10.1504/IJHFE.2019.10021010

Davies, S.E.H., Marnewick, J.L., Kamati, O.V., & Bester, D. (2023a). The power of transdisciplinary research for business innovation: The case of Rooibos as a potential ergogenic sport drink. 8th International Conference on Business and Management Dynamics, 7 – 8 September 2022, South Africa. Published in peer reviewed proceedings. Current Aspects in Business, Economics and Finance Vol. 8. Editor Dr. Chun-Chien Kuo. Publisher - B P International ISBN-13 (15) 978-81-19039-04-3 (Print); ISBN-13 (15) 978-81-19039-06-7 (eBook). Print ISBN: 978-81-19039-04-3Online ISBN: 978-81-19039-06-7 DOI Number: https://doi.org/10.9734/bpi/cabef/v8/4496

Davies, S.E.H., Marnewick, J.L., Kamati, O.V., & Bester, D.J. (2023b). Transdisciplinary Synergy: The Benefits for Postgraduate Learning and Research Through Integrated Support at a University of Technology in South Africa. The Paris Conference on Education (PCE2023), Maison de la Chimie, Paris, France, | Friday, June 16, 2023 to Monday, June 19, 2023.

Deschepper, R., Six, S., Vandeweghe, N., De Couck, M., Gidron, Y., Depoorter, A.-M., & Bilsen, J. (2017). Linking numbers to perceptions and experiences: Why we need transdisciplinary mixed-methods combining neurophysiological and qualitative data. Criminal Justice and Behavior, 10(2), 1609–1629. https://doi.org/10.1177/0093854820953449

Department of Environmental Affairs (DoEA) (2014). Traditional Knowledge Associated with rooibos and honeybush Species in South Africa; 2014. https://www.dffe.gov.za/sites/default/files/reports/traditionalknowledge_rooibosandhoneybushspecies_report.pdf

Engelbrecht, P. (2006). The implementation of inclusive education in South Africa after ten years of democracy. European Journal of Psychology of Education, 21(3), 253-264. http://download.springer.com/static/pdf/625

art%253A10.1007%252FBF03173414.pdf?auth66=1393688373_906fca13d83dd82e8dff7e7b10f80b93&ext=.pdf

Farnsworth, N.R., Akerele, O., Bingel, A.S., Soejarto, D.D., & Guo, Z. (1985). Medicinal plants in therapy. Bulletin of the World Health Organisation, 63, 965–981.

Farnsworth, N.R., & Bingel, A.S. (1977). Problems and prospects of discovering new drugs from higher plants by pharmacological screening. In: Wagner, H., Wolff, P. (Eds.), New Natural Products and Plant Drugs with Pharmaceutical, Biological or Therapeutic Activity. Springer-Verlag, Heidelberg, Germany.

Fiehn, O. (2001). Combining Genomics, Metabolome Analysis, and Biochemical Modelling to Understand Metabolic Networks. Comp. Functional. Genomics, 2, 155–168.

Fortuin, K. P. J., & Van Koppen, C. S. A. (2016). Teaching and learning reflexive skills in inter-and transdisciplinary research: A framework and its application in environmental science education. Environmental Education Research, 22(5), 697–716.

Garthe, I., & Maughan, R.J. (2018). Athletes and Supplements: Prevalence and Perspectives. The International Journal of Sport Nutrition and Exercise Metabolism, 28, 126–138.

Gieger, C., Geistlinger, L., Altmaier, E., Hrabe de Angelis, M., Kronenberg, F., Meitinger,. T, et al. (2008). Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genetics, 4:e1000282

Ghazalpour, A., Bennett, B.J., Shih, D., Che, N., Orozco, L., Pan, C., et al. (2014). Genetic regulation of mouse liver metabolite levels. Molecular Systems Biology, 10:730.

Ginevičienė, V., Utkus, A., Pranckevičienè, E., Semenova, E.A., Hall, E.C.R., & Ahmetov, I.I. (2022). Perspectives in Sports Genomics. Biomedicines, 10, 298. https://doi.org/10.3390/biomedicines10020298

Glittenberg, J. (2004). A transdisciplinary, transcultural model for health care. Journal of Transcultural Nursing, 15(1), 6–10.

Gohil, K., Viguie, C., Stanley, W.C., Brooks, G.A., & Packer, L. (1988) ‘Blood glutathione oxidation during physical exercise’. Journal of Applied Physiology, 64(1), 115–119.

Goldblatt, P., Manning, J.C., & Snijman, D. (2005) Cape plants: corrections and additions to the flora. 1. African Biodiversity & Conservation, 35, 35–46.

Goldstein, E.R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., & Wilborn, C. (2010). International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition, 7(1), 5. doi:10.1186/1550-2783-7-5. PMID:20205813.

Guest, N.S., Horne, J., Vanderhout, S.M., & El-Sohemy, A. (2019). Sport nutrigenomics: Personalized nutrition for athletic performance. Frontiers in Nutrition, 6(February), 1–16.

Guilherme, J.P.L.F., & Lucía, A. (2019). Introduction to genetics of sport and exercise. In Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions; Barh, D., Ahmetov, I., Eds.; Academic Press: Cambridge, MA, USA, 2019; pp. 3–22.

GrandView (2023). Sports Nutrition Market Size, Share & Trends Analysis Report By Product Type (Sports Supplements, Sports Drinks), By Application, By Formulation, By Consumer Group, By End-user, By Sales Channel, By Region, And Segment Forecasts, 2023 – 2030.

https://www.grandviewresearch.com/industry-analysis/sports-nutrition-market

Hadorn, G.H., Biber-Klemm, S., Grossenbacher-Mansuy, W., Hoffman-Riem, H., Joye, D., Pohl, C. et al., (2008). ‘The emergence of transdisciplinarity as a form of research’, in G.H. Hardon, H. Hoffman-Riem, S. Biber-Klemm, W. Grossenbacher- Mansuy, D. Joye, C. Pohl, et al. (eds.), Handbook of transdisciplinary research, (pp. 19–39), Springer, Bern.

Hasin, Y., Seldin, M., & Lusis, A. (2017). Multi-omics approaches to disease. Genome Biology, 18(83), DOI 10.1186/s13059-017-1215-1

Hesseling, P.B., Klopper, J.F., & Van Heerden, P.D.R. (1979). Die effek van rooibostee op ysterabsorpsie. South African Medical Journal, 55, 631-632.

Hölsgens, R., Wascher, E., Bauer, C., Boll, J., Bund, S., Dankwart-Kammoun, S., Heese, I., Schrot, K., Schultze, J., & Tenambergen R. (2023). Transdisciplinary Research along the Logic of Empowerment: Perspectives from Four Urban and Regional Transformation Projects. Sustainability, 15(5):4599. https://doi.org/10.3390/su15054599

Jantsch, E. (1970). Inter- and Transdisciplinary University: a systems approach to education and innovation. Policy Science, 1(1), 403-28. doi: 10.1007/BF00145222.

Joubert, E., Gelderblom, W.C.A., Louw, A., de Beer, D., 2008. South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides – a review. Journal of Ethnopharmacology, 119, 376–412.

Joubert, E., Schulz, H., 2006. Production and quality aspects of rooibos tea and related products. A review. The Journal of Applied Botany and Food Quality, 80, 138–144.

Joubert, E., & de Beer, D. (2011). Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical. South African Journal of Botany, 77, 869–886. doi:10.1016/j.sajb.2011.07.004

Kamati, O.V., Davies, S.E.H., Marnewick, J.L. (2020): Effect of dietary rooibos on exercise-induced oxidative stress, performance and recovery. CPUT Post Graduate Conference.

Kamati, O.V., Davies, S.E.H, Marnewick J, Sheik N and Bester D (2021). Effect of dietary rooibos on exercise-induced oxidative stress, performance, and recovery. PAMGS and Free Radical Research Africa Conference (Virtual), 15-16 September 2021.

Kamati OV, Marnewick, J.M., Davies, S.E.H., and Louw, R. (2022a). Investigating the Association between exercise-induced pro-inflammatory response and genetic individuality: Applied Microbial and Health Biotechnology Institute (AMHBI) symposium, Cape Peninsula University of Technology, Cape Town, South Africa, 7 September 2022.

Kamati, O.V., Marnewick, J.M., Davies, S.E.H., and Lowe, R. (2022b). Rooibos, a potential oxidative stress modulator and ergogenic aid. CPUT postgraduate conference.

Kayser, O. (2018). Ethnobotany and Medicinal Plant Biotechnology: From Tradition to Modern Aspects of Drug Development. Planta Medica, 84(12/13), 834-838. DOI: 10.1055/a-0631-3876

Kerksick, C.M., Wilborn, C.D., Roberts, M.D., Smith-Ryan, A., Kleiner, S.M., Jager, R., Collins, R., Cooke, M., Davis, J.N, Galvan, E., Greenwood, M., Lowery, L.M., Wildman, R., Antonio, J., & Kreider, R.B. (2018). ISSN exercise & sports nutrition review update: research & recommendations. Journal of the International Society of Sports Nutrition, 15(1), 38.

Kettunen, J., Tukiainen, T., Sarin, A.P., Ortega-Alonso, A., Tikkanen, E., Lyytikainen, L.P., et al. (2012). Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nature Genetics, 44, 269–76.

Knapik, JJ, R.A., Steelman, S.S., Hoedebecke, K.G., Austin, E.K., Farina, H.R., Lieberman. (2016). Prevalence of dietary supplement use by athletes: systematic review and meta-analysis. Sports Medicine, 46(1), 103–123.

Koeppen, B.H., & Roux, D.G. (1965). Aspalathin: a novel C-glycosylflavonoid from Aspalathus linearis. Tetrahedron Letters, 3497–3503.

Inanami, O. Asanuma, T., Inukai, N., Jin, T., Shimokawa, S., Kasai, N., Nakano, M., Sato, F., Kuwabara, M. (1995). The suppression of age-related accumulation of lipid peroxides in rat brain by administration of Rooibos tea (Aspalathus linearis). Neuroscience Letters, 196, 85-88.

Lafay, S., Jan, C., Nardon, K., Lemaire, B., Ibarra, A., Roller, M., Houvenaeghel, M., Juhel, C. and Cara, L. (2009). ‘Grape extract improves antioxidant status and physical performance in elite male athletes’. The Journal of Sports Science and Medicine, 8(3), 468–480.

Lang, D.J., Wiek, A., Bergmann, M., Stauffacher, M., Martens, P., Moll, P., Swilling, M., and Thomas, C.J. (2012). Transdisciplinary research in sustainability science: practice, principles, and challenges. Sustainable Science. 7, 25–43. https://doi.org/10.1007/s11625-011-0149-x.

Lawrence, M.G., Williams, S., Nanz, P., and Renn, O. (2022). Characteristics, potentials, and challenges of transdisciplinary research. One Earth, 5(1), 44-61. https://doi.org/10.1016/j.oneear.2021.12.010

Lightsey, D.M., & Attaway, J.R. (1992). Deceptive tactics used in marketing purported ergogenic aids. Journal National Strength and Conditioning Association, 14(2), 26-31.

Linder, H.P. (2003) The radiation of the Cape flora, southern Africa. Biological Reviews, 78, 597–638.

Londe, A. M., Marocolo, M., Marocolo, I. C., Fisher, J., Neto, O. B., Souza, M. V. C., et al. (2018). Wearing colored glasses can influence exercise performance and testosterone concentration? Sports Medicine International. Open 02, E46–E51. doi: 10.1055/a-0601-7250

Lozano, R. (2006), “Incorporation and institutionalization of SD into universities: breaking though barriers to change”, Journal of Cleaner Production, 14(9/11), 787-796.

Madsen, R., Lundstedt, T., & Trygg, J. (2010). Chemometrics in metabolomics–a review in human disease diagnosis. Analytica Chimica Acta, 659, 23–33.

Manning, J., & Goldblatt, P. (2012). Plants of the Great Cape Floristic Region 1: The Core Cape Flora, Strelitzia 29. South African National Biodiversity Institute, Pretoria.

Marnewick, J.L., Gelderblom, W.C.A., & Joubert, E. (2000). An investigation on the antimutagenic properties of South African herbal teas. Mutation Research, 471,157–166.

Marnewick, J.L. (2004). Chemopreventive properties of two South African herbal teas, rooibos tea (Aspalathus linearis) and honeybush tea (Cyclopia intermedia) utilizing different short-term in vivo and in vitro carcinogenesis models. Ph.D. (Biochemistry) Dissertation. University of Stellenbosch, Stellenbosch, South Africa.

Marnewick, J.L., Joubert, E., Joseph, S., Swanevelder, S., Swart, P., & Gelderblom,W.C.A. (2005). Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas. Cancer Letters, 224, 193–202.

Marnewick, J. L. (2009). Rooibos and Honeybush: recent advances in chemistry, biological activity and pharmacognosy. (In H. Juliani, et al. (Eds.): African Natural Plant Products: New Discoveries and Challenges in Chemistry and Quality;.; ACS Symposium Series; American Chemical Society: Washington, DC, 2010. p. 277-280).

Marnewick, J.L., Rutenbach, F., Venter, I., Neethling, H., Blackhurst, D.M., Wolmarans, P., & Macharia, M. (2011). Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameter in adults at risk for cardiovascular disease. Journal of Ethnopharmacology, 133, 46-52.

Marocolo, M., Billaut, F., & da Mota, G. R. (2018). Ischemic preconditioning and exercise performance: an ergogenic aid for whom? Frontiers in Physiology, 9, 1874. doi: 10.3389/fphys.2018.0 1874

Marocolo, M., Simim, M. A. M., Bernardino, A., Monteiro, I. R., Patterson, S. D., & da Mota, G. R. (2019). Ischemic preconditioning and exercise performance: shedding light through smallest worthwhile change. European Journal of Applied Physiology, 119, 2123–2149. doi: 10.1007/s00421-019-04 214-6

Maughan RJ. (1999). Nutritional ergogenic aids and exercise performance. Nutrition Research Reviewer,12:233280.

Mayer J., & Bullen B. (1960). Nutrition and athletic performance. Physiological Reviews, 40, 369-397.

Moreno, B., Veiga, S., Sánchez-Oliver, A.J., Domínguez, R., & Morencos, E. (2022). Analysis of Sport Supplement Consumption by Competitive Swimmers According to Sex and Competitive Level. Nutrients, 14, 3218. https://doi.org/ 10.3390/nu14153218

Morton, J.F. (1983). Rooibos tea, aspalathus linearis, a caffeineless, low-tannin beverage. Economic Botony, 37(2), 164–173. https://doi.org/10.1007/BF02858780

Mota, G.R., and Marocolo, M. (2022). Editorial: Ergogenic Aids: Physiological and Performance Responses. Frontiers in Sports and Active Living, 4:902024.doi: 10.3389/fspor.2022.902024

Nagoya protocol. (2010). Available from: https://www.cbd.int/abs/doc/protocol/nagoya-protocol-en. pdf [accessed Sep 16 2022].

Nicolescu, B. (1985). Nous, la particule et le monde [We, the particle and the world]. Paris, France: Le Mail.

Nicolescu, B. (2002). Manifesto of transdisciplinarity [Trans. K-C. Voss]. New York, NY: SUNY.

Nicolescu, B. (2012). ‘The need for transdisciplinarity in higher education in a globalized world’, Transdisciplinary Journal of Engineering & Science, 3, 11–18.

Nowotny, H. (2003). ‘The potential of transdisciplinarity’, in Rethinking interdisciplinarity, interdisciplines project. https://www.worldfishcenter.org/sites/ default/files/The%20potential%20for%20transdisciplinarity.pdf

National Inquiry Services Centre (NISC)(2023).

https://www.nisc.co.za/products/101/books/a-contribution-to-the-south-african-materia-medica#

National environmental management biodiversity act (NEMBA)(2004). 2004 [cited Sep 17 2022]. Available from: https://www.environment.gov.za/sites/default/files/legislations/nema_amen dment_act10.pdf.

Ng, S.B., Turner, E.H., Robertson, P.D., Flygare, S.D., Bigham, A.W., Lee, C., et al. (2009). Targeted capture and massively parallel sequencing of 12 human exomes. Nature, 461, 272–6. (7261):272-6. doi: 10.1038/nature08250.

Packer, L. (1997) ‘Oxidants, antioxidant nutrients and the athlete’. Journal of Sports Sciences, 15(3), 353–363.

Pantsi, W.G., Marnewick, J.L., Esterhuyse, A.J., Rautenbach, F., & van Rooyen, J. (2011). Rooibos (Aspalathus linearis) offers cardiac protection against ischaemia/ reperfusion in the isolated perfused rat heart. Phytomedicine, 18, 1220 1228. doi:10.1016/j.phymed.2011.09.069

Pappe, L. (1868). Florae Capensis Medicae Prodromus, Or, An Enumeration Of South African Indigenous Plants Used As Remedies By The Colonists Of The Cape Of Good Hope, Publisher A. S. Robertson.

Patti, G.J., Yanes, O., & Siuzdak, G. (2012). Innovation: Metabolomics: the apogee of the omics trilogy. Nature Reviews Molecular Cell Biology, 13, 263–9.

Pennington, D., Ebert-Uphoff, I., Freed, N., Martin, J., & Pierce, S. A. (2020). Bridging sustainability science, earth science, and data science through interdisciplinary education. Sustainability Science, 15, 647–661.

Piaget J. (1972). The epistemology of interdisciplinary relationships. In: Apostel L, editor. Interdisciplinarity: problems of teaching and research in universities. Paris: Organization for Economic Co-operation and Development (OECD); (pp.127-39).

Reed J.D. (1977). They hunger for success. Sports Illustrated, 46, 65-68 (February 28).

Reid, W.V., Sittenfeld, A., Laird, S.A., Janzen, D.H., Meyer, C.A., Gollin, M.A., Gamez, R., & Juma, C. (1993). BIODIVERSITY PROSPECTING: Using Genetic Resources for Sustainable Development. World Resources Institute (WRI), USA Instituto Nacional de Biodiversidad (INBio), Costa Rica Rainforest Alliance, USA; African Centre for Technology Studies (ACTS), Kenya. A Contribution to the: WRI/IUCN/UNEP Global Biodiversity Strategy May 1993, Copyright © 1993 World Resources Institute. All rights reserved. ISBN 0-915825-89-9

Richardson, D.P. (1996). Functional foods–shades of gray: an industry perspective, Nutrition Reviews, 11(2), S174–185.

Rinschen, M.M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019). Identification of bioactive metabolites using activity metabolomics. Nature Reviews Molecular Cell Biology, 20, 353–367.

Roberfroid, M.B. (1997). Health benefits of non-digestible oligosaccharides. Advances in Experimental Medicine and Biology, 427, 211–219.

Rong, Y., Geng, Z., & Lau, B.H. (1996). ‘Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells’. Free Radical Biology and Medicine, 20(1), 121–127.

Rosenfield, P.L. (1992). The potential for transdisciplinary research for sustaining and extending linkages between the health and social sciences. Social Science & Medicine, 35(11), 1343–57.

South African Rooibos Council (SARC)(2022). Khoi and San to share in benefits of rooibos; 2022 [cited Sep 26 2022]. Available from: https://sarooibos.co.za/khoi-and-san-to-share-in-benefits-of-rooibos/.

South African Rooibos Council (SARC)(2023). https://southafrica.co.za/south-african-rooibos-council.html

Sasaki, Y.F., Yamada, H., Shimoi, K., Kator, K., & Kinae, N. (1993). The clastogen-suppressing effects of green tea, Po-lei tea and Rooibos tea in CHO cells and mice. Mutation Research, 286, 221-232.

Schapera, I. (1930). The Khoisan Peoples of South Africa. Bushmen and Hottentots. Routledge and Kegan Paul Ltd, London.

Schroeder, D., Chennells, R., Louw, C., Snyders, L., & Hodges, T. (2020). The Rooibos Benefit Sharing Agreement–Breaking New Ground with Respect, Honesty, Fairness, and Care. Cambridge Quarterly of Healthcare Ethics, 29(2), 285-301. doi: 10.1017/S0963180119001075, PMID 31685054.

Scott, G., Tilbury, D., Deane, L. & Sharp, L. (2012). Turnaround Leadership for Sustainability in Higher Education, Australian Government, Office for Learning and Teaching Canberra.

Shimamura, N., Miyase, T., Umehara, K., Warashina, T., & Fujii, S. (2006). Phytoestrogens from Aspalathus linearis. Biological and Pharmaceutical Bulletin, 29, 1271-1274.

Shin, S.Y., Fauman, E.B., Petersen, A.K., Krumsiek, J., Santos, R., Huang, J., et al. (2014). An atlas of genetic influences on human blood metabolites. Nature Genetics, 46, 543–50.

Smith, A. (2011). A contribution to the South African Materia Medica Publishers: Cory Library, Rhodes University as part of the Eastern Cape Reprints series. ISBN 13: 978-0-86810-469-0

Smyth, T.S. (2017). Transdisciplinary Pedagogy: A Competency Based Approach for Teachers and Students to Promote Global Sustainability. Journal of Interdisciplinary Studies in Education, 5(2), 64-72.

Snykers, F.O., & Salemi, G. J. (1974). Studies of South African medicinal plants. Part I. Quercetin as the major in vitro active compound of rooibos tea. South African Chemical. Institute, 27, 5-7.

Tanaka, M., Wang, G., & Pitsiladis, Y.P. (2016). Advancing sports and exercise genomics: moving from hypothesis-driven single study approaches to large multi-omics collaborative science. Physiological Genomics, 48, 173–174.doi:10.1152/physiolgenomics.00009.2016.

Thunberg, C.P. (1986). Travels at the Cape of Good Hope, 1772–1775: based on the English edition, London 1793–1795, edited by Emeritus Prof. Vernon Siegfried Forbes, translation from the Swedish revised by J. & I. Rudner, Cape Town: Van Riebeck Society, xlviii–366 p. (p. 44).

Tucker, R., & Collins, M. (2012). What makes champions? A review of the relative

contribution of genes and training to sporting success. British Journal of Sports Medicine, 46, 555–561.

Van der Bijl-Brouwer, M, Kligyte, G. & Key, T. (2021). A Co-evolutionary, Transdisciplinary Approach to Innovation in Complex Contexts: Improving University Well-Being, a Case Study. She Ji: The Journal of Design, Economics, and Innovation, 7(4), 565-588, ISSN 2405-8726, https://doi.org/10.1016/j.sheji.2021.10.004.

Van Itallie, T.B., Sinisterra, L., & Stare F.J. (1956). Nutrition and athletic performance. Journal of the American Medical Association, 162, 1120-1126.

Van Wyk, B-E., Van Oudtshoorn, B., & Gericke, N. (1997). In Medicinal Plants of South Africa. Briza Publications, Pretoria, South Africa, 1997; pp. 290.

Voight, B.F., Kang, H.M., Ding, J., Palmer, C.D., Sidore, C., Chines, P.S., et al. (2012). The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genetics, 8, e1002793.

Walton, E., & Engelbrecht, P. (2022). Inclusive education in South Africa: path dependencies and emergences, International Journal of Inclusive Education. http://doi:10.1080/13603116.2022.2061608

Wackerhage, H., Miah, A., Harris, R.C., Montgomery, H.E., & Williams, A.G. (2009). Genetic research and testing in sport and exercise science: A review of the issues. Journal of Sports Science, 27, 1109–1116.

Wang, W.Y., Barratt, B.J., Clayton, D.G.,& Todd, J.A. (2005). Genome-wide association studies: theoretical and practical concerns. Nature Reviews Genetics, 6, 109–18.

Williams, M.H. (1989). Nutritional ergogenic aids and athletic performance. Nutrition Today, 24, 7-14.

Williams, C. (1998). Diet and sports performance. In Oxford Textbook of Sport Medicine, 2nd ed., [M Harries, C Williams, WD Stanish and LL Micheli, editors]. New York: Oxford University Press, 1998, (pp. 77–97).

World Health Organization (WHO)(2013). WHO Traditional Medicine Strategy: 2014–2023. Geneva, Switzerland: WHO Press; 2013

Wynberg, R. (2017). Making sense of access and benefit sharing in the rooibos industry: towards a holistic, just and sustainable framing. South African Journal of Botony, 110, 39-51. doi: 10.1016/j.sajb.2016.09.015.

Yoshikawa, T., Natio, Y., Oyamada, H., Ueda, S., Tangigawa, T., Takemura, T., Sugino, S., & Kondo, M. (1990). Scavenging effects of Aspalathus linearis (rooibos tea) on active oxygen species. Advances in Experimental Medicine and Biology, 264, 171–174.

Zhang, X. (2002). World Health Organization. WHO Traditional Medicine Strategy, Geneva, (pp. 2002–2005).

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2024-01-12