The extract of Schinus terebinthifolius Raddi intensifies morphological  alterations in the colon of diabetic rats

Camiliany Pereira da Silva; Marcelo Wecsley Ferreira  Araújo; Camila Cavicchioli  Sehaber-Sierakowski; Flávia Cristina Vieira  Frez; Camila Cristina  Iwanaga; Marcelo Biondaro Gois; Jacqueline Nelisis Zanoni; Neide Martins  Moreira; Catchia Hermes-Uliana

doi:10.23925/1984-4840.2023v25a10

Autores

Camiliany Pereira da Silva Universidade Federal de Mato Grosso do Sul
Marcelo Wecsley Ferreira Araújo Universidade Federal de Mato Grosso do Sul
Camila Cavicchioli Sehaber-Sierakowski Universidade Estadual de Maringá
Flávia Cristina Vieira Frez Universidade Estadual de Maringá
Camila Cristina Iwanaga Universidade Estadual de Maringá
Marcelo Biondaro Gois Universidade Federal de Rondonópolis
Jacqueline Nelisis Zanoni Universidade Estadual de Maringá
Neide Martins Moreira Universidade Estadual do Oeste do Paraná
Catchia Hermes-Uliana Universidade Federal de Mato Grosso do Sul

DOI:

https://doi.org/10.23925/1984-4840.2023v25a10

Palavras-chave:

Diabetes mellitus, Compostos bioativos, Antioxidantes, Células caliciformes, Linfócitos intraepiteliais

Resumo

Existem diversos desafios no tratamento do diabetes mellitus. Alguns desses desafios incluem a descoberta de compostos bioativos com potencial para serem coadjuvantes no tratamento do diabetes mellitus. Neste estudo foram investigados os efeitos do extrato hidroetanólico de Schinus terebinthifolius Raddi sobre parâmetros fisiológicos e morfológicos do cólon de ratos diabéticos. Para esse propósito, 16 ratos com 90 dias de idade foram distribuídos aleatoriamente em quatro grupos: Normoglicêmico (N); normoglicêmico, tratado com (50 mg/kg) o extrato hidroetanólico de S. terebinthifolius Raddi (NA); diabéticos induzidos por estreptozotocina (D); e diabéticos induzidos por estreptozotocina, tratados com o extrato hidroetanólico de S. terebinthifolius Raddi (DA). Os ratos diabéticos apresentaram diarreia, perda de peso, aumento na ingestão de água e alimentos e níveis elevados de glicose no sangue. Além disso, nos grupos NA, D e DA, observaram-se atrofia de toda a parede intestinal e submucosa, hipertrofia da muscular da mucosa e alterações na histoarquitetura das criptas intestinais e enterócitos. Adicionalmente, foram observadas mudanças na remodelação de colágeno e nos gânglios do sistema nervoso entérico, assim como alterações quantitativas em células caliciformes e linfócitos intraepiteliais somente nos grupos D e DA. Nossos resultados mostram que o tratamento com o extrato de S. terebinthifolius Raddi não protegeu o cólon dos danos causados pelo diabetes nem reverteu parâmetros fisiológicos. Além disso, o tratamento causou alterações morfológicas no cólon de ratos normoglicêmicos e intensificou os danos causados pelo diabetes.

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