Surgery with intraoperative neurophysiology for microsurgical resection of high-grade gliomas in the motor area in patients asleep with general anesthesia

A better result than that obtained with functional tests in awake patients?

Authors

  • Nadjila Gabriela Santana Sidani Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde https://orcid.org/0000-0002-3431-5356
  • Íris Cristina Brock Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde
  • Paulo Henrique Pires de Aguiar Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

DOI:

https://doi.org/10.23925/1984-4840.2020v22i4a6

Keywords:

Craniotomia, Gliomas, Neurocirurgia, Neurofisiologia

Abstract

Introduction: Diffuse gliomas are primary tumors of the central nervous system that remain a challenge for medicine, despite improvements in treatment techniques, due to their dynamic patterns of growth and behavior. One of the treatment alternatives currently studied is based on the percentage of resection and the eloquent area involved. The first is an important independent prognostic factor that defines patient survival. Objective: To show the casuistry of the asleep approach to surgery of tumors in the motor area. Method: Retrospective study in patients undergoing asleep surgical resection of high-grade gliomas, with intraoperative somatosensitive motor electrophysiological monitoring, of the partial, subtotal and total types, using craniotomy and microsurgery. Results analysis was based on the evaluation of postoperative Evolution by the Karnofsky Scale. Results: For the verified sample, it can be suggested that the asleep operative technique is safe to be employed in the motor areas. All patients who presented deficits died due to the aggressive nature of the disease. Conclusion: The asleep operative technique has been found to be safe for use in the motor areas, having extremely low intraoperative complications, and its prognostic evolution depends on the initial aggressiveness of the tumor.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Mendes GA, Ongaratti BR, Semmelmann Pereira-Lima JF. Epidemiologia de uma série de tumores primários do sistema nervoso central. Arq Bras Neurocir Braz Neurosurg. 2014;33(04):279-83. https://doi.org/10.1055/s-0038-1626227

Barbosa ARSO. Craniotomia para resseção de astrocitoma em área funcional com doente acordado [dissertação]. Porto: Instituto de Ciências Biomédicas Abel Salazar. Universidade do Porto; 2012.

Henrique M, Faria G, Maria R, Helena S, Rabenhorst B. Estratégias auxiliares para graduação dos tumores astrocíticos segundo os critérios histopatológicos estabelecidos pela OMS. J Bras Patol Med Lab. 2006;2(5):401-10. https://doi.org/10.1590/S1676-24442006000500012

Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 2002;61(3):215-25; discussion 226-9. https://doi.org/10.1093/jnen/61.3.215

Viterbo MB. Astrocitomas do sistema nervoso central: correlação do grau de ressecação tumoral e prognóstico [dissertação]. São Paulo: Hospital Heliópolis; 2008.

Bogosavljevic V, Tasic G, Nestorovic B, Jovanovic V, Rakic M, Samardzic M. Surgical treatment of glioblastoma multiforme localized in the motor area of the brain using the technique of cortical electrostimulation. Turk Neurosurg. 2012;22(2):135-40. https://doi.org/10.5137/1019-5149.JTN.3980-10.2

Lopes TG, Castilho-Fernandes A, Tedesco AC. Ampla caracterização do glioblastoma e abordagens terapêuticas. Rev Univ Vale Rio Verde. 2012;10(2):12-25. https://doi.org/10.5892/ruvrv.2012.102.1225

Lucena RDCG, Mello RJV, Lessa JR, Cavalcante GM, Ribeiro M. Correlação clínico-topográfica em glioblastomas multiformes nas síndromes motoras: significados fisiopatológicos. Arq Neuro-Psiquiatr. 2006;64(2 B):441-5. https://doi.org/10.1590/S0004-282X2006000300017

Viegas SFJ. Tumor cerebral incidência, diagnóstico e tratamento [Internet]. Faro: Universidade do Algarve; 2010. 35 [acessado em 25 maio 2018]. Disponível em:

https://sapientia.ualg.pt/bitstream/10400.1/4913/1/PROJECTO_SusanaViegas_2010.pdf

Shah KB, Hayman LA, Chavali LS, Hamilton JD, Prabhu SS, Wangaryattawanich P, et al. Glial tumors in brodmann area 6: Spread pattern and relationships to motor areas. Radiographics. 2015;35(3):793-803. https://doi.org/10.1148/rg.2015140207

Badke GL, Panagopoulos AT, Aguiar GB, Veiga JCE. Glioblastoma multiforme em idosos: uma revisão sobre seu tratamento com ênfase na abordagem cirúrgica. Arq Bras Neurocir. 2014;33(1):45-51. https://doi.org/10.1055/s-0038-1626199

Fonseca CO, Fischer JSG, Masini M, Futuro D, Caetano R, Gattass CR, Santos TQ. Oligodendrogliomas: a genética molecular e o desenvolvimento de estratégia terapêutica adjuvante. Arq Bras Neurocir: Braz Neurosurg. 2007;26(1):08-15.

Ojemann G. Cognitive mapping through electrophysiology. Epilepsia. 2010;51(Suppl. 1):72-5. https://doi.org/10.1111/j.1528-1167.2009.02453.x

Alves P. Abordagem terapêutica de gliomas cerebrais de alto grau [dissertação]. Covilhã: Universidade da Beira Interior; 2014.

Hathout L, Ellingson B, Pope W. Modeling the efficacy of the extent of surgical resection in the setting of radiation therapy for glioblastoma. Cancer Sci. 2016;107(8):1110-6. https://doi.org/10.1111/cas.12979

Published

2022-06-28

How to Cite

1.
Sidani NGS, Brock Íris C, Aguiar PHP de. Surgery with intraoperative neurophysiology for microsurgical resection of high-grade gliomas in the motor area in patients asleep with general anesthesia: A better result than that obtained with functional tests in awake patients?. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2022Jun.28 [cited 2024Jul.5];22(4):163-7. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/47693

Issue

Section

Original Article