Effect of prone position on oxygenation of patients with COVID-19 under invasive mechanical ventilation
DOI:
https://doi.org/10.23925/1984-4840.2025v27a2Keywords:
COVID-19, Prone Position, Physical Therapy Modalities, Respiratory Distress SyndromeAbstract
Objective: To evaluate the behavior of the ventilation/perfusion ratio of patients with positive COVID-19 under mechanical ventilation (MV) after the prone position. Methodology: Quantitative, descriptive, retrospective research in an intensive care unit (ICU) COVID-19 from May to December 2020. Data were collected: age, sex, comorbidities, PaO2 collected from arterial blood gases, FiO2 collected of the mechanical ventilator at the time of blood gas collection to calculate the PaO2/FiO2 ratio. This relationship was calculated at the pre-prone, one-hour post-prone, six-hour post-prone, and four-hour post-supine moments. The time spent on MV (in days), the SAPS III score, the length of stay in the ICU (in days), and the outcomes of discharge or death in the unit were also collected. All data were collected from patients' electronic medical records. Results: 71 patients with a mean age of 58.7 ± 15.5 years, 60.5% male, were selected. The most prevalent comorbidity was arterial hypertension with 60.6%. The mean PaO2/FiO2 ratio before prone positioning was 113.11 mmHg, with a significant increase (p < 0.0001) of 91.97 mmHg after six hours in the prone position, with a mean duration of 19h46min ± 0h14min in the prone position. There was 55.5% of death among patients. Conclusion: The prone position caused a significant increase in oxygenation in patients
with COVID-19 under MV.
References
Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: the reality and challenges. J Microbiol Immunol Infect. 2020;53(3):436-43. doi: 10.1016/j.jmii.2020.03.034.
Ghelichkhani P, Esmaeili M. Prone position in management of COVID-19 patients: a commentary. Arch Acad Emerg Med. 2020;8(1):e48.
Barbas CSV, Ísola AM, Farias AMC, Cavalcanti AB, Gama AMC, Duarte ACM, et al. Recomendações brasileiras de ventilação mecânica 2013. Rev Bras Ter Intensiva. 2014;26(2):89-121. doi: 10.5935/0103-507X.20140017.
Jochmans S, Mazerand S, Chelly J, Pourcine F, Sy O, Thieulot-Rolin N, et al. Duration of prone position sessions: a prospective cohort study. Ann Intensive Care. 2020;10(1):66. doi: 10.1186/s13613-020-00683-7.
Kallet RH. A comprehensive review of prone position in ARDS. Respir Care. 2015;60(11):1660-87. doi: 10.4187/respcare.04271.
Niikawa H, Okamoto T, Ayyat KS, Itoda Y, Farver CF, Mccurry KR. The protective effect of prone lung position on ischemia-reperfusion injury and lung function in an ex vivo porcine lung model. J Thorac Cardiovasc Surg. 2016;157(1):425-33. doi: 10.1016/j.jtcvs.2018.08.101.
Scholten EL, Beitler JR, Prisk GK, Malhotra A. Treatment of ARDS with prone positioning. Chest. 2016;151(1):215-24. doi: 10.1016/j.chest.2016.06.032.
Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, et al; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013;368(23):2159-68. doi: 10.1056/NEJMoa1214103.
Marini JJ, Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;23(22):2329-30. doi: 10.1001/jama.2020.6825.
Qadri SK, Ng P, Toh TSW, Loh SW, Tan HL, Lin CB, et al. Critically Ill patients with COVID-19: a narrative review on prone position. Pulm Ther. 2020;6(2):233-46. doi: 10.1007/s41030-020-00135-4.
Salles Neto LL, Martins CB, Chaves AA, Konstantyner TCRO, Yanasse HH, Campos CBL, et al. Forecast UTI: application for predicting intensive care unit beds in the context of the COVID-19 pandemic. Epidemiol Serv Saude. 2020;29(4):e2020391. doi: 10.1590/S1679-49742020000400023. Erratum in: Epidemiol Serv Saude. 2020;29(5):e2020111. doi: 10.1590/S1679-49742020000500020.
Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al; COVID-19 Lombardy ICU Network. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-81. doi: 10.1001/jama.2020.5394. Erratum in: JAMA. 2021;325(20):2120. doi: 10.1001/jama.2021.5060.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2025 Revista da Faculdade de Ciências Médicas de Sorocaba

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Os autores no momento da submissão transferem os direitos autorais, assim, os manuscritos publicados passam a ser propriedade da revista.
O conteúdo do periódico está licenciado sob uma Licença Creative Commons 4.0, esta licença permite o livre acesso imediato ao trabalho e que qualquer usuário leia, baixe, copie, distribua, imprima, pesquise ou vincule aos textos completos dos artigos, rastreando-os para indexação, passá-los como dados para o software, ou usá-los para qualquer outra finalidade legal.
Este obra está licenciada com uma Licença