Rare ovarian Sertoli-leydig cell tumor: a case report

Authors

  • Ana Carolina Lopes Freitas Santa Casa de Misericórdia de Vitória
  • Jonnymar Lima Santa Casa de Misericórdia de Vitória
  • Juliana Pessoa Santa Casa de Misericórdia de Vitória
  • Helena Lucia Barroso dos Reis Universidade Federal do Espirito Santo
  • Eduardo Frizzera Scardua Santa Casa de Misericórdia de Vitória
  • Antonio Chambô Filho Santa Casa de Misericórdia de Vitória

Keywords:

Sertoli-Leydig cell tumor, ovarian neoplasms, middle aged.

Abstract

ABSTRACT
Sertoli-Leydig cell tumor (SLCT), also known as arrenoblastoma, is a rare cancer of the ovaries that is part of a group called sex-cord tumors. Although this malignant neoplasm may appear at any age, it is more common in young adults. The Sertoli-Leydig cell tumors represent less than 0.5% of ovarian primitive neoplasms, typically produce androgens which may evolve into virilization of the patients. In this report, we present a case of SLCT in a 56-year old patient. The clinical and laboratorial characteristics and histopathological findings of this rare tumor were discussed in this work, as well as the treatment and follow-up that should be given to this disease.Key-words: Sertoli-Leydig cell tumor; ovarian neoplasms; middle aged.

Downloads

Download data is not yet available.

Author Biographies

Ana Carolina Lopes Freitas, Santa Casa de Misericórdia de Vitória

Médica da Santa Casa de Misericórdia de Vitória

Jonnymar Lima, Santa Casa de Misericórdia de Vitória

Médico da Santa Casa de Misericórdia de Vitória

Juliana Pessoa, Santa Casa de Misericórdia de Vitória

Médica da Santa Casa de Misericórdia de Vitória

Helena Lucia Barroso dos Reis, Universidade Federal do Espirito Santo

Coordenadora do Ambulatório de DST/AIDS de Ginecologia do Hospital Universitário Cassiano Antônio de Moraes da Universidade Federal do Espírito Santo

Eduardo Frizzera Scardua, Santa Casa de Misericórdia de Vitória

Professor de Ginecologia e Obstetrícia da Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória

Antonio Chambô Filho, Santa Casa de Misericórdia de Vitória

Professor de Ginecologia e Obstetrícia da Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória

References

Einhorn LH. Testicular cancer. In: Goldman L, Schafer AI, editores. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011. chap 206.

Markham M. Gynecologic cancers. In: Goldman L, Schafer AI, editores. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011. chap 205.

Sanz OA, Martinez PR, Guarch RT, Goni MJI, Alcazar JLZ: Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient. Maturitas. 2007;57:214-6.

Dickerson RD, Putman MJ, Black ME, Pinto KR, Diamond NG, Marynic S, et al. Selective ovarian vein sampling to localize a Leydig cell tumor. Fertil Steril. 2005;84(1):218.

Ali FSM, Stanaway SERS, Zakhour HD, Spearing G, Bowen-Jones D. A case of hirsutism due to bilateral diffuse ovarian Leydig cell hyperplasia in a post-menopausal woman. Eur J Intern Med. 2003;14(7):432-3.

Serov SF, Scully RE, Sobin LH. Histological typing of ovarian tumours. Geneva: WHO; 1973. (International Histological Classification of Tumours, no. 9).

Roth LM. Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2006;25(3):199-215.

Zhang M, Cheung MK, Shin JY, Kapp DS, Husain A, Teng NN, et al. Prognostic factors responsible for survival in sex cord stromal tumors of the ovary: an analysis of 376 women. Gynecol Oncol. 2006;104(2):396-400.

Cruceyra BG, Tejido SA, Duarte OJM, Garcia de La Torre JP, De La Morena GJM, Silva VM, et al. Leydig cell tumor: report of 8 cases and review of the literature. Actas Urol Esp. 2002;26(1):36-40.

Villaplana GH, Rosino EH, Cubillana PL, Egea LA, Pastor GS, Gómez GG. Leydig cell tumor: comments on 5 cases. Actas Urol Esp. 1994;18(9):880-4.

Baker PM, Oliva E. Immunohistochemistry as a tool in the differential diagnosis of ovarian tumours: an update. Int J Gynecol Pathol. 2004;24(1):39-55.

Appetecchia M, Cela V, Bernardi F, Burelli A, Cionini R, Pucci E. Sertoli-Leydig cell androgens-estrogens secreting tumor of the ovary: ultra-conservative surgery. Eur J Obstet Gynecol Reprod Biol. 2004;116(1):113-6.

Marcelino M, Nobre E, Conceicão J, Lopes L, Vilar H, França M, et al. Um caso raro de hiperandrogenismo: tumor ovárico bilateral de células de Leydig. Acta Med Port. 2010;23(1):113-8.

Kostopoulou E, Talerman A. Ovarian Sertoli-Leydig cell tumor of intermediate differentiation with inmature skeletal muscle heterologous elements. Acta Obstet Gynecol Scand. 2003;82:197-8.

Hillemanns P, Kimmig R, Arnholdt H. Conservative management of Sertoli-Leydig cell tumor of the ovary. Acta Obstet Gynecol Scand. 1997;76(6): 604-5.

Published

2014-09-24

How to Cite

1.
Freitas ACL, Lima J, Pessoa J, dos Reis HLB, Scardua EF, Chambô Filho A. Rare ovarian Sertoli-leydig cell tumor: a case report. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2014Sep.24 [cited 2024Dec.21];16(3):152-4. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/16291

Issue

Section

Case Report