Effects of statins on bone tissue

Authors

  • Newton Maciel Oliveira FCMS/PUC-SP
  • Stephanie Victoria Camargo Leão Edelmuth FCMS/PUC-SP
  • Khatharine Suheyhuky Aoki FCMS/PUC-SP
  • Karlla Karollynna de Fátima Gaiotto FCMS/PUC-SP

Keywords:

bone and bones, hydroxymethylglutaryl-CoA reductase inhibitors, osteogenesis

Abstract

Bone tissue has the capacity of repairing itself without leaving a scar after an injury or surgical resections. For large defects, on the other hand, the structural loss requires the use of bone grafts, to which growth and cellular differentiation factors can be added. Recent studies have shown that statins, a class of drugs used to lower cholesterol levels, have pleiotropic effects, which include increase of bone formation by osteoblasts and inhibition of bone resorption by osteoclasts. The current study is an update on the actions of these drugs and its mechanism on bone tissue. However, due to the existence of scientific papers that deny these effects, more research should be conducted as to clarify the matter.

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Author Biographies

Newton Maciel Oliveira, FCMS/PUC-SP

Professor do Depto. de Morfologia e Patologia FCMS/PUC-SP

Stephanie Victoria Camargo Leão Edelmuth, FCMS/PUC-SP

Acadêmica do curso de Medicina FCMS/PUC-SP

Khatharine Suheyhuky Aoki, FCMS/PUC-SP

Acadêmica do curso de Medicina FCMS/PUC-SP

Karlla Karollynna de Fátima Gaiotto, FCMS/PUC-SP

Acadêmica do curso de Medicina FCMS/PUC-SP

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Published

2015-06-26

How to Cite

1.
Oliveira NM, Edelmuth SVCL, Aoki KS, Gaiotto KK de F. Effects of statins on bone tissue. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2015Jun.26 [cited 2024May19];17(2):54-7. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/21141

Issue

Vol. 17 No. 2 (2015)

Section

Update

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