Pulmonary hemorrhage resulting from leptospirosis

Authors

  • Mauro Razuk Filho Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde – Sorocaba (SP), Brasil.
  • Cristina Schmitt Cavalheiro Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde – Sorocaba (SP), Brasil.
  • José Víctor de Miranda Pedroso Pontifícia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde – Sorocaba (SP), Brasil.

DOI:

https://doi.org/10.5327/z1984-4840201621876

Keywords:

leptospirosis, hemorrhage, lung, respiratory distress syndrome, adult

Abstract

Leptospirosis is one of the most widespread zoonoses in the world, although the mechanisms responsible for the pathogenesis of spirochetes of the genus Leptospira are largely unknown. Human infection occurs either by direct contact with infected animals or indirectly, through contact with water or soil contaminated with urine, as the spirochetes easily penetrate human skin. The present report exposes the case of a female patient, diagnosed with leptospirosis after having had contact with a dog infected by Leptospira sp. that developed pulmonary hemorrhage, acute respiratory distress syndrome and acute renal failure.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Evangelista KV, Coburn J. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiol. 2010;5(9):1413-25.

Benschop J, Heuer C, Jaros P, Collins-Emerson J, Midwinter A, Wilson P. Sero-prevalence of leptospirosis in workers at a New Zealand slaughterhouse. N Z Med J. 2009;122(1307):39-47.

Desai S, van Treeck U, Lierz M, Espelage W, Zota L, Sarbu A, et al. Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007. Clin Infect Dis. 2009;48(6):691-7.

Morgan J, Bornstein SL, Karpati AM, Bruce M, Bolin CA, Austin CC, et al. Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998. Clin Infect Dis. 2002;34(12):1593-9.

Stern EJ, Galloway R, Shadomy SV, Wannemuehler K, Atrubin D, Blackmore C, et al. Outbreak of leptospirosis among adventure race participants in Florida, 2005. Clin Infect Dis. 2010;50(6):843-9.

McBride A, Athanazio DA, Reis MG, Ko AI. Leptospirosis. Curr Opin Infect Dis. 2005;18(5):376-86.

Lehmann JS, Matthias MA, Vinetz JM, Fouts DE. Leptospiral pathogenomics. Pathogens. 2014;3(2):280-308.

Pappas G, Papadimitriou P, Siozopoulou V, Christou L, Akritidis N. The globalisation of leptospirosis: worldwide incidence trends. Int J Infect Dis. 2008;12(4):351-7.

Lau CL, Smythe LD, Craig SB, Weinstein P. Climate change, flooding, urbanisation and leptospirosis: fuelling the fire? Trans R Soc Trop Med Hyg. 2010;104(10):631-8.

Leshem E, Meltzer E, Schwartz E. Travel-associated zoonotic bacterial diseases. Curr Opin Infect Dis. 2011;24(5):457-63.

Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser J, et al. Neglected tropical diseases: diagnosis, clinical management, treatment and control. Swiss Med Wkly. 2012;142:w13727.

Ricaldi JN, Vinetz JM. Leptospirosis in the tropics and in travellers. Curr Infect Dis Rep. 2006;8(1):51-8.

Marotto PC, Nascimento CM, Eluf-Neto J, Marotto MS, Andrade L, Sztainbok J, et al. Acute lung injury in leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality. Clin Inf Dis. 1999; 29(6):1561-3.

Wuthiekanun V, Chierakul W, Limmathurotsakul D, Smythe LD, Symonds ML, Dohnt MF, et al. Optimization culture of Leptospira from humans with leptospirosis. J Clin Microbiol. 2007;45(4):1363-5.

Medeiros FR, Spichler A, Athanazio DA. Leptospirosis- associated disturbances of blood vessels, lungs and hemostasis. Acta Trop. 2010;115(1-2):155-62.

Courtin JP, Di Francia M, Du Couëdic I, Poubeau P, Mahé C, Bapteste J, et al. Respiratory manifestations of leptospirosis. A retrospective study of 91 cases (1978-1984). Rev Pneumol Clin. 1998;54(6):382-92.

Park SK, Lee SH, Rhee YK, Kang SK, Kim KJ, Kim MC, et al. Leptospirosis in Chonbuk Province of Korea in 1987: a study of 93 patients. Am J Trop Med Hyg. 1989;41(3):345-51.

Goncalves AJR, Carvalho JEM, Guedes e Silva JB, Rozembaum R, Vieira ARM. Hemoptise/s e síndrome de angústia respiratória do adulto como causas de morte na leptospirose. Mudanças de padrões clínicos e anatomopatológicos. Rev Soc Bras Med Trop. 1992;25(4):261-70.

Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR. Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis. 2007;11(1):142-8.

Helmerhorst HJ, van Tol EN, Tuinman PR, de Vries PJ, Hartskeerl RA, Grobusch MP, et al. Severe pulmonary manifestation of leptospirosis. Neth J Med. 2012;70(5):215-21.

Published

2016-07-19

How to Cite

1.
Razuk Filho M, Cavalheiro CS, Pedroso JV de M. Pulmonary hemorrhage resulting from leptospirosis. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2016Jul.19 [cited 2024Jul.5];18(2):117-20. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/21876

Issue

Section

Case Report