Eficácia do confrei em ulcerações nos pés relacionadas ao diabetes: ensaio clínico randomizado controlado e duplo-cego

Luis Rafael Leite Sampaio; Luziana Nara Alves do Nascimento; Adriana Célia Cardoso dos Santos; Elisângela Tavares da Silva Barros; Manuel Alves da Cunha Neto; Ana Alinne Gomes da Penha; Tays Pires Dantas; Andréia Lacerda de Sousa Barros; Sarah Emanuelle Matias Penha; Woneska Rodrigues Pinheiro; Rita Neuma Dantas Cavalcante de Abreu

doi:10.23925/1984-1840.2024v26a34

Authors

Luis Rafael Leite Sampaio Universidade Regional do Cariri (URCA)
Luziana Nara Alves do Nascimento Universidade de Fortaleza (UNIFOR)
Adriana Célia Cardoso dos Santos Universidade de Fortaleza (UNIFOR)
Elisângela Tavares da Silva Barros Universidade de Fortaleza (UNIFOR)
Manuel Alves da Cunha Neto Universidade Federal Rural do Semi-Árido (UFERSA)
Ana Alinne Gomes da Penha Universidade Regional do Cariri (URCA)
Tays Pires Dantas Universidade Regional do Cariri (URCA)
Andréia Lacerda de Sousa Barros Universidade Regional do Cariri (URCA)
Sarah Emanuelle Matias Penha Universidade Regional do Cariri (URCA)
Woneska Rodrigues Pinheiro Universidade Regional do Cariri (URCA)
Rita Neuma Dantas Cavalcante de Abreu Universidade de Fortaleza (UNIFOR)

DOI:

https://doi.org/10.23925/1984-1840.2024v26a34

Keywords:

Comfrey, Ulcer, Diabetes Mellitus, Wound Healing

Abstract

Objective: To evaluate the effects of external use of comfrey on diabetes-related foot ulceration in the outpatient stomatherapy nursing clinic of a quaternary public teaching hospital. Methods: This is a randomized-controlled, parallel, double-blind, two-arm, quantitative clinical trial conducted with 19 participants. The control group used hydrogel, while the intervention group used a 5% ointment made from the aqueous extract of comfrey leaves. The groups used the formula for 60 days, applying it every 24 hours, and were reassessed every 15 days. To collect data, an instrument was used consisting of a section with clinical information related to the injury and another dedicated to the measurements and dimensions of the injury. Results: There was an increase in the percentage of lesion contraction in the group using 5% comfrey on the 15th (p < 0.05), 30th (p < 0.01), 45th (p < 0.05) and 60th (p < 0.05) days of treatment, rapid improvement in the Texas classification and in the predominance of granulation tissue after the 15th day, in relation to the control group. Conclusion: The analysis of this study's results, it was possible to observe that comfrey promoted faster healing, decreased exudate and pain levels, improved Texas classification, tissue repair in a shorter time, increased percentage of lesion contraction, and improved tissue perfusion.

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