Mean platelet volume (MPV) analysis in patients with coronary artery disease

Authors

  • Bianca Ribeiro Rodrigues FCMS/PUC-SP
  • Hudson Hübner França FCMS/PUC-SP
  • José Roberto Maiello FCMS/PUC-SP
  • Marcelo Gil Cliquet FCMS/PUC-SP

Keywords:

blood platelets, platelet count, coronary artery disease.

Abstract

ABSTRACT
Platelets have a predominant role in the pathogenesis of Acute Coronary Syndromes (ACS). It is believed that the mean platelet size, evaluated by the mean platelet volume (MPV), is a sensitive indicator of platelet reactivity and trombogenicity potential. Several studies have found associations between the MPV and the ACS or the occurrence of Acute Myocardial Infarction (AMI). The reasons for this are not very well known, but may be due to platelet aggregation or consumption. The aim of this study was to identify a relation between the MPV value and the presence of coronary artery disease, and between alterations in this value and risk factors for coronary artery disease, such as age, sex, hypertension, diabetes, smoking, dislipidemia, obesity and family history. All patients (N = 72) had an elevated MPV, mean of 11.57 fL. No statistically significance was found in the groups with different risk.

Downloads

Download data is not yet available.

Author Biographies

Bianca Ribeiro Rodrigues, FCMS/PUC-SP

Acadêmica do curso de medicina FCMS/PUC-SP

Hudson Hübner França, FCMS/PUC-SP

Professor do Depto. de Medicina FCMS/PUC-SP. In memoriam (1929-2012)

José Roberto Maiello, FCMS/PUC-SP

Professor do Depto. de Medicina FCMS/PUC-SP

Marcelo Gil Cliquet, FCMS/PUC-SP

Professor do Depto. de Medicina FCMS/PUC-SP

References

Kierszenbaum AL. Histologia e biologia celular: uma introdução à patologia. Rio de janeiro: Elsevier; 2004.

Lee GR. Wintrobe Hematologia clínica. 11ª ed. São Paulo: Manole; 2004.

Kumar V, Abbas AK, Fausto N. Patologia: bases patológicas das doenças. 7ª ed. Rio de Janeiro: Elsevier; 2005.

Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol. 2006; 59:146-9.

Pabón Osuna P, Nieto Ballesteros F, Moriñigo Muñoz JL, Sanchez Fernandez PL, Arribas Jiménez A, Dominguez MD, Martín Luengo C. Influencia del volumen plaquetario medio sobre el pronóstico a corto plazo del infarto agudo de miocardio. Rev Esp Cardiol. 1998; 51:816-22.

Kiliçli-Camur N, Demirtunç R, Konuralp C, Eskiser A, Başaran Y. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit. 2005; 11(8):CR387-92.

Pizzulli L, Yang A, Martin JF, Lüderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J. 1998; 19:80-4.

Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002; 117:399-404.

Venturinelli ML, Hovnan A, Soeiro AM, Nicolau JC, Ramires JAF, D'Amico EA, Serrano Júnior CV. Ativação plaquetária em formas clínicas distintas da doença arterial coronariana (papel da P-selectina e de outros marcadores nas anginas estável e instável). Arq Bras Cardiol. 2006; 87:446-50.

Armaganijan D. Ativação plaquetária nas formas distintas da doença arterial coronariana. Arq Bras Cardiol. 2006; 87:401-2.

Gladwin AM, Martin JF. The control of megakaryocyte ploidy and platelet production: biology and pathology. Int J Cell Cloning. 1990; 8:291-8.

Kishk YT, Trowbridge EA, Martin JF. Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site. Clin Sci (London). 1985; 68(4):419-25.

Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005; 46(2):284-90.

Van der Loo B, Martin JF. A role for changes in platelet production in the cause of acute coronary syndromes. Arterioscler Thromb Vasc Biol. 1999; 19:672-9.

Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka-Karna J, Radziwon P, Lipska A. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thromb Res. 2006; 118(2):199-204.

Zimmet J, Ravid K. Polyploidy: occurrence in nature, mechanisms, and significance for the megacaryocyteplatelet system. Exp Hematol. 2000; 28:3-16.

Smith NM, Pathansali R, Bath PMW. Platelets and stroke. Vasc Med. 1999; 4:165-72.

Cameron HA, Phillips R, Ibbotson RM, Carson PH. Platelet size in myocardial infarction. Br Med J. 1983; 287:449-51.

Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. 2004; 35:1688-91.

Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R et al. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler. Thromb Vasc Biol. 1997; 17:802-7.

Debili N, Massé JM, Katz A, Guichard J, Breton-Gorius J, Vainchenker W. Effects of the recombinant hematopoietic growth factors interleukin 3, interleukin 6, stem cell factor and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells. Blood. 1993; 82:84-95.

Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983; 67:968-77.

Harris TB, Ballard-Barbasch R, Madans J, Makuc DM, Feldman JJ. Overweight, weight loss, and risk of coronary artery disease in older women: the NHANES epidemiologic follow-up study. Am J Epidemiol. 1993; 137:1318-27.

World Health Organization. The Asia-Pacific perspective: redefining obesity and its treatment [Internet]. Australia: WHO; 2000 [acesso em 07 fev. 2012]. Disponível em: http://www.wpro.who.int/nutrition/documents/docs/Redefiningobesity.pdf

Wendland AE, Farias MG, Manfroi WC. Volume plaquetário médio e doença cardiovascular . J Bras Patol Med Lab. 2009; 45(5):371-8.

Downloads

Published

2013-03-25

How to Cite

1.
Rodrigues BR, França HH, Maiello JR, Cliquet MG. Mean platelet volume (MPV) analysis in patients with coronary artery disease. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2013Mar.25 [cited 2024Dec.21];15(1):192-7. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/8901

Issue

Vol. 15 No. 1 (2013)

Section

Original Article

License

Os autores no momento da submissão transferem os direitos autorais, assim, os manuscritos publicados passam a ser propriedade da revista.

O conteúdo do periódico está licenciado sob uma Licença Creative Commons 4.0, esta licença permite o livre acesso imediato ao trabalho e que qualquer usuário leia, baixe, copie, distribua, imprima, pesquise ou vincule aos textos completos dos artigos, rastreando-os para indexação, passá-los como dados para o software, ou usá-los para qualquer outra finalidade legal.