Myelodysplastic syndromes: clinical laboratory aspects and prognostic classification

Authors

  • Antonianna Furtado Cavalcante Vecina FCMS/PUC-SP
  • Rafael Vicente Lucena FCMS/PUC-SP
  • Wagner Lapa Pinheiro Júnior FCMS/PUC-SP
  • Marcelo Gil Cliquet FCMS/PUC-SP

Keywords:

myelodysplatic syndromes, prognosis, hematologic diseases.

Abstract

ABSTRACT
Myelodysplastic syndromes (MDS) comprise a spectrum of clonal myeloid diseases (neoplastic) that are characterized by ineffective hematopoiesis (dysplastic), cytopenias and an evolution trend for acute leukemias. Due to the variability of clinical presentations, patients with MDS were initially grouped based on morphological features - the group classification French-American-British (FAB). This classification has been recently improved by the World Health Organization (WHO) that incorporated immunophenotyping and cytogenetic data of the clinical and morphological parameters used in the FAB classification. The International Prognostic Index (IPSS) complemented this classification taking into account the percentage of marrow blasts, cytogenetic risk group and number of cytopenias to define distinct groups in terms of prognosis.

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Author Biographies

Antonianna Furtado Cavalcante Vecina, FCMS/PUC-SP

Professora do Depto. de Medicina FCMS/PUC-SP

Rafael Vicente Lucena, FCMS/PUC-SP

Acadêmico do curso de Medicina FCMS/PUC-SP

Wagner Lapa Pinheiro Júnior, FCMS/PUC-SP

Acadêmico do curso de Medicina FCMS/PUC-SP

Marcelo Gil Cliquet, FCMS/PUC-SP

Professor do Depto. de Medicina FCMS/PUC-SP

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Published

2013-06-27

How to Cite

1.
Vecina AFC, Lucena RV, Pinheiro Júnior WL, Cliquet MG. Myelodysplastic syndromes: clinical laboratory aspects and prognostic classification. Rev. Fac. Ciênc. Méd. Sorocaba [Internet]. 2013Jun.27 [cited 2024Nov.19];15(2):1-5. Available from: https://revistas.pucsp.br/index.php/RFCMS/article/view/12984

Issue

Vol. 15 No. 2 (2013)

Section

Review

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