Avaliação dos níveis das transaminases dos pacientes com infecção pelo Plasmodium vivax atendidos em um centro de referência para tratamento da malária no Estado de Mato Grosso

Elisane de Freitas Pereira; Izabele Linhares Ferreira de Melo Cavalcante; Lilian Gomes dos Santos Tezini; Luciano Teixeira Gomes

doi:10.23925/1984-4840.2017v19i3a4

Authors

Elisane de Freitas Pereira Curso de Medicina pela Faculdade de Ciências Biomédicas de Cacoal - FACIMED
Izabele Linhares Ferreira de Melo Cavalcante Curso de Medicina pela Faculdade de Ciências Biomédicas de Cacoal - FACIMED
Lilian Gomes dos Santos Tezini Curso de Medicina pela Faculdade de Ciências Biomédicas de Cacoal - FACIMED
Luciano Teixeira Gomes Núcleo de Estudos de Doenças Infecciosas e Tropicais de Mato Grosso, Faculdade de Medicina, Universidade Federal de Mato Grosso

DOI:

https://doi.org/10.23925/1984-4840.2017v19i3a4

Keywords:

malaria, vivax, Plasmodium vivax, transaminases

Abstract

Objective: To determine hepatic markers (transaminases) in patients with malaria caused by Plasmodium vivax. Methods: This was a retrospective cross-sectional study, including patients who presented monoinfection with P. vivax. The Mann- Whitney U test or Student’s t test were used to compare the mean activity of transaminases according to the clinical and epidemiological classification of the infected patient. Kruskal-Wallis test was used to compare the mean transaminase activity according to the classification of the infection. Values of p<0.05 were considered significant. Results: Individuals younger than 7 years of age had a higher activity of glutamic oxalacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) — respectively, 68.7 U/L and 79.8 U/L — in relation to patients aged 8-59 years (GOT 29.8 U/L and GPT 39.2 U/L) and over 60 years (GOT 32.5 U/L and GPT 34 U/L). The mean serum GOT dosage of all patients included in the study was 31.99 U/L and of GPT was 41.1 U/L. The activity of glutamic pyruvic transaminase in the primoinfected patients was higher than those reinfected or with relapse, being 65.6 U/L versus 36.2 U/L and 32.7 U/L, respectively. Conclusion: Children have a higher activity of transaminases than individuals older than seven years of age. The patient with previous infection by P. vivax presents lower serum levels of transaminase activity than the primoinfected. Individuals with relapse episodes have lower values of the enzymes evaluated than those with reinfection or primoinfection.

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